新的研究表示，暴露於內分泌絮亂的化學物質(（endocrine-disrupting chemicals，EDC)中，可能導致人類面臨健康威脅-糖尿病和肥胖。EDC可能阻斷或干擾人體的內分泌激素。通過劫持人體的化學信使，內分泌干擾物可以改變細胞的發育和生長方式。目前所知的內分泌干擾物包括雙酚A，磷苯二甲酸酯(存在於塑膠材料，化妝品和殺蟲劑)，EDC普遍存在於我們生存的環境中。
近日在瑞士日內瓦的國際管理大會（ICCM4）上，科學家聲明需用科學方法來限制EDC的健康風險。這項聲明建立在該協會2009年的報告，試圖用科學證據找到EDC對人類健康的影響。隨後幾年有更多的研究進展，暴露於EDC環境對於糖尿病與肥胖的風險增加有關，也發現會導致激素相關的癌症，如乳癌、卵巢癌、前列腺癌，或是引起神經發育的問題。
內分泌干擾物(EDC)對於未出生的胎兒影響尤其嚴重。動物實驗研究發現，在胎兒其少量的EDC可以導致出生之後罹患肥胖的問題。另外的研究發現，一些EDC的目標是胰臟的β、α?胞、脂肪細胞和肝細胞，導致胰島素抵抗，增加二型糖尿病罹患風險。
科學家認為，一方面需要繼續確定那些化學分子可能導致什麼疾病，這些化學分子的危險濃度，以及有怎樣的因果關係。此外，減少EDC暴露於環境中的對策。尤其是孩子們，在他們發育階段更需要保護他們，讓他們遠離危險性的化學分子。業者一定要注意化學分子的汙染，控制EDC的汙染源，這點很重要，對於社會公眾健康有重要意義。
相關文獻:
TOPIC:
Executive Summary to EDC-2: The Endocrine Society's Second Scientific Statement on Endocrine-Disrupting Chemicals
ABSTRATE:
This Executive Summary to the Endocrine Society's second Scientific Statement on environmental endocrine-disrupting chemicals (EDCs) provides a synthesis of the key points of the complete statement. The full Scientific Statement represents a comprehensive review of the literature on seven topics for which there is strong mechanistic, experimental, animal, and epidemiological evidence for endocrine disruption, namely: obesity and diabetes, female reproduction, male reproduction, hormone-sensitive cancers in females, prostate cancer, thyroid, and neurodevelopment and neuroendocrine systems. EDCs such as bisphenol A, phthalates, pesticides, persistent organic pollutants such as polychlorinated biphenyls, polybrominated diethyl ethers, and dioxins were emphasized because these chemicals had the greatest depth and breadth of available information. The Statement also included thorough coverage of studies of developmental exposures to EDCs, especially in the fetus and infant, because these are critical life stages during which perturbations of hormones can increase the probability of a disease or dysfunction later in life. A conclusion of the Statement is that publications over the past 5 years have led to a much fuller understanding of the endocrine principles by which EDCs act, including nonmonotonic dose-responses, low-dose effects, and developmental vulnerability. These findings will prove useful to researchers, physicians, and other healthcare providers in translating the science of endocrine disruption to improved public health.
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